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A 17-year-old female diagnosed with bipolar II disorder was treated for emotional lability with quetiapine. Two-lead electrocardiography revealed frequent monomorphic premature ventricular contraction (PVC) during an electroencephalography examination. Twenty-four-hour Holter electrocardiography revealed 0.6% uniform frequent PVCs and indicated that the readministration and second-time withdrawal of quetiapine markedly increased (7.1%) and decreased the frequency of PVC (1.1%), respectively. This case indicates that quetiapine can cause PVC as a serious side effect. Copyright © 2012 Elsevier Inc. All rights reserved.


Akiko Deguchi, Masayuki Nakamura, Takehiro Hayashi, Akira Sano. Quetiapine-induced frequent premature ventricular contraction. General hospital psychiatry. 2012 Mar-Apr;34(2):211.e1-3

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PMID: 22245024

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