Successful alternative treatment containing vindesine for acute lymphoblastic leukemia with Charcot-Marie-Tooth disease.

Mizuho Ichikawa, Daisuke Suzuki, Jun Inamoto, Junjiro Ohshima, Yuko Cho, Shinji Saitoh, Makoto Kaneda, Akihiro Iguchi, Tadashi Ariga

Department of Pediatrics, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. mizuho@med.hokudai.ac.jp

Journal of pediatric hematology/oncology 2012 Apr

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Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies. Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which, like VCR, is widely used to treat malignancies. The case of an 11-year-old female patient with CMT type 1A who developed severe peripheral neuropathy induced by VCR given for her acute lymphoblastic leukemia is reported. Alternative treatment containing vindesine instead of VCR led to a successful outcome without a relapse of leukemia or neurological worsening of CMT.

Citation

Mizuho Ichikawa, Daisuke Suzuki, Jun Inamoto, Junjiro Ohshima, Yuko Cho, Shinji Saitoh, Makoto Kaneda, Akihiro Iguchi, Tadashi Ariga. Successful alternative treatment containing vindesine for acute lymphoblastic leukemia with Charcot-Marie-Tooth disease. Journal of pediatric hematology/oncology. 2012 Apr;34(3):239-41