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Spinosad is a novel macrolide insecticide produced by Saccharopolyspora spinasa, widely used in agriculture. Here its biosynthetic pathway, and key regulatory nodes were reviewed and analyzed. A synthetic strategy to reprogram spinosad biosynthetic pathway was proposed.


Yue Li, Cheng Chang, Keqian Yang. Biosynthetic pathway and synthetic strategy of spinosad--a review]. Wei sheng wu xue bao = Acta microbiologica Sinica. 2011 Nov 4;51(11):1431-9

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PMID: 22260039

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