Praziquantel derivatives exhibit activity against both juvenile and adult Schistosoma japonicum.

Wen-wen Duan, Si-jie Qiu, Yue Zhao, Huan Sun, Chunhua Qiao, Chao-ming Xia

College of Pharmaceutical Science, Soochow University, Suzhou, China.

Bioorganic & medicinal chemistry letters 2012 Feb 15

filter terms:

A praziquantel analog 10-hydroxy praziquantel and eight praziquantel/peroxide conjugates were synthesized. The biological activity of these compounds was evaluated against juvenile and adult stages of Schistosoma japonicum. Unlike praziquantel, 10-hydroxy praziquantel exhibits activity against both juvenile and adult Schistosoma japonicumin. All hybrid compounds displayed modest to significant worm killing activity. The present study has important significance for the development of hybrid antischistosomal drugs. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

Citation

Wen-wen Duan, Si-jie Qiu, Yue Zhao, Huan Sun, Chunhua Qiao, Chao-ming Xia. Praziquantel derivatives exhibit activity against both juvenile and adult Schistosoma japonicum. Bioorganic & medicinal chemistry letters. 2012 Feb 15;22(4):1587-90