Antimycobacterial and antioxidant activities of reserpine and its derivatives.

Sabira Begum, Syeda Qamar Zehra Naqvi, Aqeel Ahmed, Saima Tauseef, Bina Shaheen Siddiqui

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. sabira@khi.comsats.net.pk

Natural product research 2012

filter terms:

In view of the attributed medicinal properties of reserpine, a number of acyl reserpine derivatives were prepared and tested for antimycobacterial activity against Mycobacterium tuberculosis, strain H(37)Rv and antioxidant activities. The results indicated that in the case of antimycobacterial activity, 10 out of 18 derivatives caused more inhibition than that caused by reserpine itself. The results of antioxidant activity revealed that acylation in benzene ring of reserpine decreases the percentage inhibition of DPPH in all the derivatives compared to the parent compound.

Citation

Sabira Begum, Syeda Qamar Zehra Naqvi, Aqeel Ahmed, Saima Tauseef, Bina Shaheen Siddiqui. Antimycobacterial and antioxidant activities of reserpine and its derivatives. Natural product research. 2012;26(22):2084-8