Flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium oleander and evaluation of cytotoxicity.

Bina Shaheen Siddiqui, Nasima Khatoon, Sabira Begum, Ahsana Dar Farooq, Kehkashan Qamar, Huma Aslam Bhatti, Syed Kashif Ali

HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. binahej@yahoo.com

Phytochemistry 2012 May

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A pentacyclic triterpene, oleanderocioic acid, two flavonoidal glycosides, quercetin-5-O-[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside and kaempferol-5-O-[α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside, and a cardenolide, oleandigoside, together with 11 known compounds, were isolated from the leaves of Nerium oleander. Their structures were elucidated on the basis of spectroscopic analysis. The growth inhibitory and cytotoxic activities of eight compounds were evaluated against the MCF-7 human breast cancer cell line using a sulforhodamine B assay. Three compounds, oleandrin, odoroside A and B were further assayed using a panel of 57 human cancer cell lines. Copyright © 2012 Elsevier Ltd. All rights reserved.]

Citation

Bina Shaheen Siddiqui, Nasima Khatoon, Sabira Begum, Ahsana Dar Farooq, Kehkashan Qamar, Huma Aslam Bhatti, Syed Kashif Ali. Flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium oleander and evaluation of cytotoxicity. Phytochemistry. 2012 May;77:238-44