Effects of acute pramipexole on male rats' preference for gambling-like rewards II.

Patrick S Johnson, Gregory J Madden, Jeffrey S Stein

Department of Applied Behavioral Science, University of Kansas, USA. patrick.johnson@aggiemail.usu.edu

Experimental and clinical psychopharmacology 2012 Jun

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Pramipexole (PPX) is a dopamine agonist medication that has been implicated in the development of pathological gambling and other impulse control disorders. Johnson, Madden, Brewer, Pinkston, and Fowler (2011) reported that PPX increased male rats' preference for gambling-like rewards (those arranged according to a variable-ratio schedule) over predictable rewards (those obtained from a fixed-ratio schedule). The present experiment explored the possibility that Johnson et al. underestimated the effects of PPX on gambling-like choices by constraining their rats' daily income. In the present experiment conducted in a closed economy, PPX produced a dose-related increase in choice of the gambling-like alternative. In a control condition, PPX did not disrupt choice, suggesting the increased preference for gambling-like rewards was not because of nonspecific drug effects. Our findings are qualitatively consistent with those of Johnson et al., although the dose-related effect and larger effect size in the current study suggest that the effect of PPX on gambling-like choices is more pronounced when income was not constrained. This finding is consistent with clinical reports suggesting PPX is related to the development of problem gambling in humans.

Citation

Patrick S Johnson, Gregory J Madden, Jeffrey S Stein. Effects of acute pramipexole on male rats' preference for gambling-like rewards II. Experimental and clinical psychopharmacology. 2012 Jun;20(3):167-72