FGF/FGFR signaling in bone formation: progress and perspectives.

Pierre J Marie, Hichem Miraoui, Nicolas Sévère

Laboratory of Osteoblast Biology and Pathology, INSERM UMR-606 and University Paris Diderot, Paris F-75475, France. pierre.marie@inserm.fr

Growth factors (Chur, Switzerland) 2012 Apr

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Fibroblast growth factors (FGFs) are important molecules that control bone formation. FGF act by activating FGF receptors (FGFRs) and downstream signaling pathways that control cells of the osteoblast lineage. Recent advances have been made in the identification of FGF/FGFR signaling pathways that control osteogenesis. Indeed, studies of mouse and human models provided novel insights into the signaling pathways that control bone formation. Genomic studies also highlighted the implication of molecular targets of FGF/FGFR signaling regulating osteoblastogenesis. Recent studies further revealed the important role of crosstalks between FGF/FGFR signaling and other signaling pathways in the regulation of osteogenesis. Finally, the importance of the mechanisms modulating FGFR degradation in the control of osteoblast differentiation has been recently revealed. This short review summarizes the recently described mechanisms underlying FGF/FGFR signaling that are involved in the control of osteoblastogenesis. This knowledge may have potential therapeutic implications in skeletal disorders characterized by abnormal bone formation.

Citation

Pierre J Marie, Hichem Miraoui, Nicolas Sévère. FGF/FGFR signaling in bone formation: progress and perspectives. Growth factors (Chur, Switzerland). 2012 Apr;30(2):117-23