New flavan and benzil isolated from Fissistigma latifolium.

Further investigation of the methanolic extract of Fissistigma latifolium resulted in two new compounds whose structures were assigned as 2,5,6,7-tetramethoxyflavan (1) and 2'-hydroxy-4',5',6'-trimethoxybenzil (2). These two compounds were determined on the basis of chemical and spectroscopic evidences. Compound 2 is the first report of benzil from Fissistigma species. 2,5,6,7-Tetramethoxyflavan (1) showed a potent inhibitory effect on superoxide anion production in formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)/cytochalasin B (CB)-activated human neutrophils.

Citation

Yu-Hsuan Lan, Yi-Ting Peng, Tran-Dinh Thang, Tsong-Long Hwang, Do-Ngoc Dai, Yann-Lii Leu, Wan-Chun Lai, Yang-Chang Wu. New flavan and benzil isolated from Fissistigma latifolium. Chemical & pharmaceutical bulletin. 2012;60(2):280-2

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PMID: 22293492

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