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In this article, we have focused on the application of non-traditional separation approach, the host-guest inclusion method, into the separation of the active component patchouli alcohol from the essential oil of Cablin potchouli Herb. The host molecule 1,1,6,6-tetraphenylhexa-2,4-diyne-1,6-diol (A) was used to selectively recognise the guest molecule patchouli alcohol (B) in the essential oil of Pogostemon cablin (Blanco) Benth through two strong hydrogen bonding. The inclusion compound was structurally determined by the single crystal X-ray diffraction. The separation effect was examined by gas chromatography for the whole essential oil and the inclusion compound, showing that the inclusion crystalline method is simple, rapid and effective for the separation of patchouli alcohol from the essential oil of C. potchouli Herb.

Citation

Jian Tong, Lei Yuan, Fang Guo, Zhong-Hua Wang, Lan Jin, Wen-Sheng Guo. Selective separation of patchouli alcohol from the essential oil of Cablin potchouli by inclusion crystalline method. Natural product research. 2013;27(1):32-6

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PMID: 22304229

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