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Assessment of antiplatelet activity of 2-aminopyrimidines.

Rajani Giridhar, Riyaj S Tamboli, R Ramajayam, Dhaval G Prajapati, M R Yadav

Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara 390 001, India. rajanimsu@rediffmail.com

European journal of medicinal chemistry 2012 Apr


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    A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

    Citation

    Rajani Giridhar, Riyaj S Tamboli, R Ramajayam, Dhaval G Prajapati, M R Yadav. Assessment of antiplatelet activity of 2-aminopyrimidines. European journal of medicinal chemistry. 2012 Apr;50:428-32

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    PMID: 22326145

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