Regulated nucleocytoplasmic transport during gametogenesis.

Yoichi Miyamoto, Peter R Boag, Gary R Hime, Kate L Loveland

Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia. Yoichi.Miyamoto@monash.edu

Biochimica et biophysica acta 2012 Jun

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Gametogenesis is the process by which sperm or ova are produced in the gonads. It is governed by a tightly controlled series of gene expression events, with some common and others distinct for males and females. Nucleocytoplasmic transport is of central importance to the fidelity of gene regulation that is required to achieve the precisely regulated germ cell differentiation essential for fertility. In this review we discuss the physiological importance for gamete formation of the molecules involved in classical nucleocytoplasmic protein transport, including importins/karyopherins, Ran and nucleoporins. To address what functions/factors are conserved or specialized for these developmental processes between species, we compare knowledge from mice, flies and worms. The present analysis provides evidence of the necessity for and specificity of each nuclear transport factor and for nucleoporins during germ cell differentiation. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Yoichi Miyamoto, Peter R Boag, Gary R Hime, Kate L Loveland. Regulated nucleocytoplasmic transport during gametogenesis. Biochimica et biophysica acta. 2012 Jun;1819(6):616-30