Polyanionic inhibitors of HIV adsorption].

Viral adsorption inhibitors represent new generation of antiviral drugs, which can be applied for the treatment of HIV infection. Given review presents the different classes of HIV entry inhibitors grouped by the processes they are targeted: the binding of viral glycoprotein gp120 with cellular receptor CD4, the following interaction of gp120 with the chemokine receptors CCR5 or CXCR4, the formation of six-helix bundle gp41 needed for the viral and cellular membrane fusion.

Citation

E O Baranova, N S Shastina, V I Shvets. Polyanionic inhibitors of HIV adsorption]. Bioorganicheskaia khimiia. 2011 Sep-Oct;37(5):592-608

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PMID: 22332354

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