MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis.

Xiao Li, Ruili Feng, Chen Huang, Haifeng Wang, Jiao Wang, Zhifeng Zhang, Huang Yan, Tieqiao Wen

Laboratory of Molecular Neural Biology, School of Life Sciences and Institute of Systems Biology, Shanghai University, Shanghai, China.

RNA biology 2012 Mar

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MicroRNAs (miRNA) are small noncoding RNAs that play important roles in cell development, differentiation and apoptosis. Recent studies showed that transmembrane protein 59 (TMEM59) affects neural stem cell (NSC) differentiation and β-amyloid precursor protein (APP) glyc osylation. In this study, we predicted that microRNA-351 (miR-351) could target TMEM59 and demonstrated that miR-351 negatively regulates TMEM59 expression in different cell types. Moreover, we found that miR-351 overexpression could lead to morphological change in the mouse NSC cell line C17.2, indicating an important role of miR-351 in the regulation of differentiation. Our investigations focused on the functions of miR-351 in the nervous system and the posttranscriptional regulation of TMEM59 by microRNA. These original findings provide promising grounds for future in-depth research into the functions of miR-351 and TMEM59 in nervous system development.

Citation

Xiao Li, Ruili Feng, Chen Huang, Haifeng Wang, Jiao Wang, Zhifeng Zhang, Huang Yan, Tieqiao Wen. MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis. RNA biology. 2012 Mar;9(3):292-301