Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes.

Veeraraghavan Usha, Adrian J Lloyd, Andrew L Lovering, Gurdyal S Besra

School of Biosciences, University of Birmingham, Birmingham, UK.

FEMS microbiology letters 2012 May

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Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

Citation

Veeraraghavan Usha, Adrian J Lloyd, Andrew L Lovering, Gurdyal S Besra. Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes. FEMS microbiology letters. 2012 May;330(1):10-6