Characterization of a novel lytic protein encoded by the Bacillus cereus E33L gene ampD as a Bacillus anthracis antimicrobial protein.

Feliza A Bourguet, Brian E Souza, Angela K Hinz, Matthew A Coleman, Paul J Jackson

Applied and environmental microbiology 2012 Apr

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Lytic proteins encoded by bacterial genomes have been implicated in cell wall biosynthesis and recycling. The Bacillus cereus E33L ampD gene encodes a putative N-acetylmuramoyl-l-alanine amidase. This gene, expressed in vitro, produced a very stable, highly active lytic protein. Very low concentrations rapidly and efficiently lyse vegetative Bacillus anthracis cells.

Citation

Feliza A Bourguet, Brian E Souza, Angela K Hinz, Matthew A Coleman, Paul J Jackson. Characterization of a novel lytic protein encoded by the Bacillus cereus E33L gene ampD as a Bacillus anthracis antimicrobial protein. Applied and environmental microbiology. 2012 Apr;78(8):3025-7