Characterization of a novel lytic protein encoded by the Bacillus cereus E33L gene ampD as a Bacillus anthracis antimicrobial protein.
Feliza A Bourguet, Brian E Souza, Angela K Hinz, Matthew A Coleman, Paul J Jackson
Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA.
Applied and environmental microbiology 2012 AprLytic proteins encoded by bacterial genomes have been implicated in cell wall biosynthesis and recycling. The Bacillus cereus E33L ampD gene encodes a putative N-acetylmuramoyl-l-alanine amidase. This gene, expressed in vitro, produced a very stable, highly active lytic protein. Very low concentrations rapidly and efficiently lyse vegetative Bacillus anthracis cells.
Citation
Feliza A Bourguet, Brian E Souza, Angela K Hinz, Matthew A Coleman, Paul J Jackson. Characterization of a novel lytic protein encoded by the Bacillus cereus E33L gene ampD as a Bacillus anthracis antimicrobial protein. Applied and environmental microbiology. 2012 Apr;78(8):3025-7
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PMID: 22344637
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