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Preterm delivery (PTD) and pre-eclampsia (PE) represent the main "obstetric syndromes," caused by multiple conditions, and characterized by complex pathogenesis. Nonetheless, recent evidences attest that deregulation of the immune system and exaggeration of inflammatory processes, taking place in the feto-placental unit, represent common central mechanisms occurring in both diseases. Tertiary prevention represents the only intervention to prevent PTD, but its incidence is still increasing. Advances in secondary prevention, focusing on risk factors and possible markers, are necessary.


Michela Torricelli, Chiara Voltolini, Maria De Bonis, Francesca Letizia Vellucci, Nathalie Conti, Filiberto Maria Severi, Felice Petraglia. The identification of high risk pregnancy: a new challenge in obstetrics. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2012 Apr;25 Suppl 1:2-5

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PMID: 22348307

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