Quantification of fexofenadine in biological matrices: a review of bioanalytical methods.

The Key Laboratory for Special Functional Materials, Henan University, Kaifeng, Henan, 475001, People's Republic of China.

Biomedical chromatography : BMC 2012 Aug

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Fexofenadine (FEX) has been extensively used for therapeutic benefits after the market withdrawal of terfenadine. Recently, the popularity of FEX has emerged owing to its unique disposition via drug transporters and, hence, it has been used as a model probe for both in vitro and in vivo investigations to understand mechanistic aspects of drug-drug interactions (DDI). Going hand in hand with the increased use of FEX in therapy and research, numerous bioanalytical methods for FEX have been published. The various published bioanalytical methods for FEX are collated in this review to provide a comprehensive information on extraction methodology, assay conditions, chromatography and detection systems. Generally, the published methods have been adequately validated and can be readily used to support the use of FEX in pharmcokinetic, DDI and mechanistic investigations. Copyright © 2012 John Wiley & Sons, Ltd.

Citation

Ming Yao, Nuggehally R Srinivas. Quantification of fexofenadine in biological matrices: a review of bioanalytical methods. Biomedical chromatography : BMC. 2012 Aug;26(8):942-61