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2'-Modified inosine analogs have been synthesized from 6-chloropurine riboside via 6-dimethylaminopurine or 6-benzyloxypurine intermediates. The dimethylaminopurine intermediate was obtained via an unusually facile dimethylamine transfer from dimethylformamide. Graphical Abstract

Citation

Fabio Casu, Rebecca K Harston, Maria A Chiacchio, Giuseppe Gumina. Synthesis of 2'-substituted inosine analogs via unusual masking of the 6-hydroxyl group. Nucleosides, nucleotides & nucleic acids. 2012;31(3):224-35

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PMID: 22356237

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