Autophagy prolongs survival after NFκB inhibition in B-cell lymphomas.

Thomas G Sommermann, Hildegard I D Mack, Ellen Cahir-McFarland

Autophagy 2012 Feb 01

filter terms:

Autophagy allows cells to survive under conditions of nutrient deprivation. We have demonstrated that autophagy inhibitors are synthetically lethal with NFκB inhibitors in B-cell lymphomas because the NFκB pathway promotes survival by increasing glucose import. When NFκB is inhibited in B-cell lymphoma, glucose import decreases and cells become sensitive to perturbations in mitochondrial metabolism and autophagy. Thus, combined inhibition of autophagy and NFκB drives cells into metabolic crisis accelerating cell death.

Citation

Thomas G Sommermann, Hildegard I D Mack, Ellen Cahir-McFarland. Autophagy prolongs survival after NFκB inhibition in B-cell lymphomas. Autophagy. 2012 Feb 01;8(2):265-7