Extracellular nucleic acids in maternal circulation as potential biomarkers for placental insufficiency.

Ilona Hromadnikova

DNA and cell biology 2012 Jul

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Since the placenta is being continuously remodeled during normal placental development, extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast microparticles, may be detected in maternal circulation during the course of normal gestation. Placental-insufficiency-related pregnancy complications have been shown to be associated with excessive placental trophoblast apoptosis and shedding of placenta debris. Recent advances in the field are reviewed with a focus on the diagnostic potential of particular molecular biomarkers and their eventual implementation in the currently used predictive and diagnostic algorithms for placental-insufficiency-related pregnancy complications.

Citation

Ilona Hromadnikova. Extracellular nucleic acids in maternal circulation as potential biomarkers for placental insufficiency. DNA and cell biology. 2012 Jul;31(7):1221-32