Total lymphocyte count is a reliable surrogate marker for CD4 cell counts after the first year of antiretroviral therapy: data from an Indonesian cohort study.

Marrigje A de Jong, Rudi Wisaksana, Hinta Meijerink, Agnes Indrati, Andre J A M van de Ven, Bachti Alisjahbana, Reinout van Crevel

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Tropical medicine & international health : TM & IH 2012 May

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Many studies have evaluated the total lymphocyte count (TLC) as a cheap surrogate marker for CD4 cells in HIV-infected patients not receiving antiretroviral therapy (ART). We assessed whether TLC can replace CD4 cell counts in evaluating the immunological response to ART. In a cohort of patients in Indonesia TLC, if measured after at least 1-year ART, correctly identified patients with <200 CD4 cells, and reliably excluded immunological failure, obviating the need for CD4 cell measurement in 43% of patients. © 2012 Blackwell Publishing Ltd.

Citation

Marrigje A de Jong, Rudi Wisaksana, Hinta Meijerink, Agnes Indrati, Andre J A M van de Ven, Bachti Alisjahbana, Reinout van Crevel. Total lymphocyte count is a reliable surrogate marker for CD4 cell counts after the first year of antiretroviral therapy: data from an Indonesian cohort study. Tropical medicine & international health : TM & IH. 2012 May;17(5):581-3