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Activation of the major histocompatibility complex (MHC) by interferon-gamma (IFN-γ) is a fundamental step in the adaptive immune response to pathogens. Here, we show that reorganization of chromatin loop domains in the MHC is evident within the first 30 min of IFN-γ treatment of fibroblasts, and that further dynamic alterations occur up to 6 h. These very rapid changes occur at genomic sites which are occupied by CTCF and are close to IFN-γ-inducible MHC genes. Early responses to IFN-γ are thus initiated independently of CIITA, the master regulator of MHC class II genes and prepare the MHC for subsequent induction of transcription.

Citation

Diego Ottaviani, Elliott Lever, Shihong Mao, Rossitza Christova, Babatunji W Ogunkolade, Tania A Jones, Jaroslaw Szary, Johan Aarum, Muhammad A Mumin, Christopher A Pieri, Stephen A Krawetz, Denise Sheer. CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma. Nucleic acids research. 2012 Jul;40(12):5262-70

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PMID: 22367884

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