The balance of benefits and risks of aspirin in primary prevention is far less clear than in secondary prevention; further data from randomized trials of individuals at intermediate cardiovascular risk are needed. Decisions about aspirin in primary prevention should be made on a case-by-case basis, and general guidelines are not justified.
Charles H Hennekens, Colin Baigent. Prevention. Aspirin in primary prevention--good news and bad news. Nature reviews. Cardiology. 2012 Feb 28;9(5):262-3
PMID: 22371106
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