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An extractive liquid-surface immobilization (Ext-LSI) system with a fungal mat formed on the surface of a liquid medium effectively enabled derepression of carbon catabolite repression. In this system, a fungicidal secondary metabolite 6-pentyl-α-pyrone was efficiently produced by Trichoderma atroviride AG2755-5NM398 despite the addition of 25% glucose or fructose. Copyright © 2012 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.


Shinobu Oda, Hiromi Araki, Shinichi Ohashi. Derepression of carbon catabolite repression in an extractive liquid-surface immobilization (Ext-LSI) system. Journal of bioscience and bioengineering. 2012 Jun;113(6):742-5

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PMID: 22382014

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