Cytogenetic diagnosis of first trimester spontaneous abortion].

About 15% of all pregnancies end in abortion. In approximately 60% of all losses are chromosomal abnormalities as a cause of pregnancy loss. To determine the importance of cytogenetic study in patients with spontaneous abortion. A series of cases of women diagnosed with spontaneous abortion less than 12 weeks and cytogenetic studies. Two groups, one group of women with normal cytogenetics and group 2 patients with abnormal cytogenetic result. 44 patients were excluded by cytogenetic study failed. We included 164 women, 55 and 65 for groups 1 and 2, respectively. In 44 cases the material was not suitable for performing karyotype. Of the 120 cases included, had abnormal karyotypes in 65 cases (54%), of which 34 cases (52.3%) were trisomy, 16 cases (24.6%) to polyploidy and 9 cases (13.8%) a monosomy. In addition, we found six cases (8.7%) with recurrent pregnancy loss. The maternal age limit increased incidence of chromosomal abnormalities occurred in the group of 31 and 35 years with 20 cases (30%). Of trisomies, the 16 were the mostfrequent with 11 cases (32.3%). The finding of 54% of chromosomal abnormalities in spontaneous abortion products demonstrates the importance of cytogenetic study, regardless of patient age and number of previous pregnancy losses.

Citation

Angel García Alonso López, Sara Bermejo Huerta, Rafael Hernández Galván, Roberto AyalaPosadas, Ariadna González del Angel, Patricia Grether González. Cytogenetic diagnosis of first trimester spontaneous abortion]. Ginecología y obstetricia de México. 2011 Dec;79(12):779-84

Mesh Tags

PMID: 22384531

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