Role of MINOS in mitochondrial membrane architecture and biogenesis.

Martin van der Laan, Maria Bohnert, Nils Wiedemann, Nikolaus Pfanner

Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universität Freiburg, 79104 Freiburg, Germany.

Trends in cell biology 2012 Apr

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Mitochondria possess a complex architecture with two membranes. The inner membrane is divided into two domains: the inner boundary membrane, which is adjacent to the outer membrane, and membrane invaginations termed cristae. Both domains are connected by tubular openings, the crista junctions. Recent studies led to the identification of a large protein complex that is crucial for establishing inner-membrane architecture. This mitochondrial inner-membrane organizing system (MINOS) interacts with protein translocases of the outer membrane that are functionally connected to the endoplasmic reticulum (ER)-mitochondria encounter structure. Here, we propose that MINOS forms a central part of an ER-mitochondria organizing network (ERMIONE) that controls mitochondrial membrane architecture and biogenesis. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Martin van der Laan, Maria Bohnert, Nils Wiedemann, Nikolaus Pfanner. Role of MINOS in mitochondrial membrane architecture and biogenesis. Trends in cell biology. 2012 Apr;22(4):185-92