Study on cytotoxicity and structure-activity relationship of HL-7702 cell exposed to naphthoquinones.

Jing Guo, Wenhua Song, Feng Ding, Jinyang Zhang, Zengtian Sun

School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Xiqing District, Tianjin, China.

Environmental toxicology and pharmacology 2012 May

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The acute cytotoxicities of six naphthoquinone compounds, including Atovaquone, Buparvaquone, Menadione, 2-acetoxy-1,4-naphthoquinone and 2-ethoxy-1,4-naphthoquinone, to HL-7702 cells were determined. The results showed that the toxicities of these naphthoquinones were characterized by a steep response pattern except for 2-hydroxy-1,4-naphthoquinone. Meanwhile, the cellular injuries were unrecoverable. Several molecular descriptors, such as the octanol-water partition coefficients (LogP), diameter (Dia) and topological index (TIndx), played an important role in the toxicity of naphthoquinones to HL-7702 cell. Our results provide a foundation for further investigation using 3D-QSAR and HQSAR to evaluate the aquatic ecological risk and the possible mechanisms of toxicity of naphthoquinones. Copyright Â© 2012 Elsevier B.V. All rights reserved.

Citation

Jing Guo, Wenhua Song, Feng Ding, Jinyang Zhang, Zengtian Sun. Study on cytotoxicity and structure-activity relationship of HL-7702 cell exposed to naphthoquinones. Environmental toxicology and pharmacology. 2012 May;33(3):408-13