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The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.


Edward F Domino, Elliot D Luby. Phencyclidine/schizophrenia: one view toward the past, the other to the future. Schizophrenia bulletin. 2012 Sep;38(5):914-9

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PMID: 22390879

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