Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds.

Alexey A Nazarov, Julie Risse, Wee Han Ang, Frederic Schmitt, Olivier Zava, Albert Ruggi, Michael Groessl, Rosario Scopelitti, Lucienne Juillerat-Jeanneret, Christian G Hartinger, Paul J Dyson

Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland. alexey.nazarov@epfl.ch

Inorganic chemistry 2012 Mar 19

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Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-d-glucofuranoside, were prepared in order to evaluate their anticancer properties compared to the parent compounds and to use them as models for intracellular visualization by fluorescence microscopy. Similar IC(50) values were obtained in cell proliferation assays, and similar levels of uptake and accumulation were also established. The X-ray structure of [{Ru(η(6)-C(6)H(5)CH(2)NHCO-anthracene)Cl(2)(pta)] is also reported. © 2012 American Chemical Society

Citation

Alexey A Nazarov, Julie Risse, Wee Han Ang, Frederic Schmitt, Olivier Zava, Albert Ruggi, Michael Groessl, Rosario Scopelitti, Lucienne Juillerat-Jeanneret, Christian G Hartinger, Paul J Dyson. Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds. Inorganic chemistry. 2012 Mar 19;51(6):3633-9