The mammalian synaptonemal complex: protein components, assembly and role in meiotic recombination.

Johanna Fraune, Sabine Schramm, Manfred Alsheimer, Ricardo Benavente

Department of Cell and Developmental Biology, Biocenter, University of Würzburg, D-97074 Würzburg, Germany.

Experimental cell research 2012 Jul 15

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The synaptonemal complex (SC) is a proteinaceous structure of chromosome bivalents whose assembly is indispensable for the successful progression of the first meiotic division of sexually reproducing organisms. In this mini-review we will focus on recent progress dealing with the composition and assembly of the mammalian SC. These advances mainly resulted from the systematic use of knockout mice for all known mammalian SC proteins as well as from protein polymerization studies performed in heterologous systems. Copyright © 2012 Elsevier Inc. All rights reserved.

Citation

Johanna Fraune, Sabine Schramm, Manfred Alsheimer, Ricardo Benavente. The mammalian synaptonemal complex: protein components, assembly and role in meiotic recombination. Experimental cell research. 2012 Jul 15;318(12):1340-6