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Sickle cell anemia is an inherited hematologic disorder associated with hemolytic and vaso-occlusive complications. An activation of coagulation is also a prominent feature of sickle cell anemia. Growing evidence indicates that coagulation may contribute to the inflammation and vascular injury in sickle cell anemia. This review focuses on tissue factor expression and its contribution to the activation of coagulation, thrombosis and vascular inflammation in sickle cell anemia. Copyright © 2012 Elsevier Ltd. All rights reserved.


Pichika Chantrathammachart, Rafal Pawlinski. Tissue factor and thrombin in sickle cell anemia. Thrombosis research. 2012 May;129 Suppl 2:S70-2

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PMID: 22398014

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