Glycemic control in the pediatric intensive care unit of Leuven: two years of experience.

Tom Van Herpe, Koen Vanhonsebrouck, Dieter Mesotten, Bart De Moor, Greet Van den Berghe

Department of Intensive Care Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium. tom.vanherpe@esat.kuleuven.be

Journal of diabetes science and technology 2012 Jan

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Stress hyperglycemia and hypoglycemia are associated with increased mortality and morbidity in critically ill patients. Three randomized controlled trials, in the surgical, medical, and pediatric intensive care unit (PICU) of the Leuven University in Belgium, demonstrated the beneficial response of tightly controlling blood glucose levels within age-adjusted narrow limits by applying intensive insulin therapy. Follow-up studies could not confirm the results obtained in the Leuven studies but revealed the complexity associated with tight glycemic control (TGC). This article gives an overview of the methodological aspects typical of the Leuven TGC concept, with the focus on the PICU. Differences between the adult and the PICU are described. This overview article might help other ICUs by addressing potential differences in clinical practice when implementing TGC. © 2012 Diabetes Technology Society.

Citation

Tom Van Herpe, Koen Vanhonsebrouck, Dieter Mesotten, Bart De Moor, Greet Van den Berghe. Glycemic control in the pediatric intensive care unit of Leuven: two years of experience. Journal of diabetes science and technology. 2012 Jan;6(1):15-21