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    In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)┬ĚH(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring. The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis.


    Shuji Noguchi, Sadahiro Fujiki, Yasunori Iwao, Keiko Miura, Shigeru Itai. Clarithromycin monohydrate: a synchrotron X-ray powder study. Acta crystallographica. Section E, Structure reports online. 2012 Mar 1;68(Pt 3):o667-8

    PMID: 22412567

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