Shuji Noguchi, Sadahiro Fujiki, Yasunori Iwao, Keiko Miura, Shigeru Itai
Acta crystallographica. Section E, Structure reports online 2012 Mar 1In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring. The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis.
Shuji Noguchi, Sadahiro Fujiki, Yasunori Iwao, Keiko Miura, Shigeru Itai. Clarithromycin monohydrate: a synchrotron X-ray powder study. Acta crystallographica. Section E, Structure reports online. 2012 Mar 1;68(Pt 3):o667-8
PMID: 22412567
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