Fragrance material review on 1,1-dimethyl-2-phenylethyl butyrate.

Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep

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A toxicologic and dermatologic review of 1,1-dimethyl-2-phenylethyl butyrate when used as a fragrance ingredient is presented. 1,1-Dimethyl-2-phenylethyl butyrate is a member of the fragrance structural group aryl alkyl alcohol simple acid esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1,1-dimethyl-2-phenylethyl butyrate were evaluated, then summarized, and includes: physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, and genotoxicity data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

D McGinty, C S Letizia, A M Api. Fragrance material review on 1,1-dimethyl-2-phenylethyl butyrate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Sep;50 Suppl 2:S439-42