Enhanced photochemical [6π] electrocyclization within the lipophilic protein binding site.

Mireia Marin, Virginie Lhiaubet-Vallet, Miguel A Miranda

Instituto de Tecnología Química UPV-CSIC, Universidad Politecnica de Valencia, Avda de Los Naranjos s/n, 46022 Valencia, Spain.

Organic letters 2012 Apr 6

filter terms:

Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins. Quantum yield determinations, combined with transient absorption spectroscopic detection of the dihydrocarbazole intermediate, demonstrate that protein encapsulation provides a subtle control of the kinetic parameters, leading to optimized efficiencies.

Citation

Mireia Marin, Virginie Lhiaubet-Vallet, Miguel A Miranda. Enhanced photochemical [6π] electrocyclization within the lipophilic protein binding site. Organic letters. 2012 Apr 6;14(7):1788-91