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A practical, mild and highly selective protocol for the monodeuteration of a variety of arenes and heteroarenes is presented. Catalytic amounts of Ag(I) salts in DMSO/D(2)O are shown to facilitate the deutero-decarboxylation of ortho-substituted benzoic and heteroaromatic α-carboxylic acids in high yields with excellent levels of deuterium incorporation. This journal is © The Royal Society of Chemistry 2012


Rachel Grainger, Arif Nikmal, Josep Cornella, Igor Larrosa. Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids. Organic & biomolecular chemistry. 2012 Apr 28;10(16):3172-4

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PMID: 22418863

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