Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids.
Rachel Grainger, Arif Nikmal, Josep Cornella, Igor Larrosa
School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS, London, UK.
Organic & biomolecular chemistry 2012 Apr 28A practical, mild and highly selective protocol for the monodeuteration of a variety of arenes and heteroarenes is presented. Catalytic amounts of Ag(I) salts in DMSO/D(2)O are shown to facilitate the deutero-decarboxylation of ortho-substituted benzoic and heteroaromatic α-carboxylic acids in high yields with excellent levels of deuterium incorporation. This journal is © The Royal Society of Chemistry 2012
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Rachel Grainger, Arif Nikmal, Josep Cornella, Igor Larrosa. Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids. Organic & biomolecular chemistry. 2012 Apr 28;10(16):3172-4
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PMID: 22418863
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