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TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β receptor activity is a critical step for signaling regulation. This review focuses on our recent understanding of regulation of TGF-β receptor activity.
Citation
Fei Huang, Ye-Guang Chen. Regulation of TGF-β receptor activity. Cell & bioscience. 2012 Mar 15;2:9
PMID: 22420375
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