Photo-degradation products of pramipexole.

Eiji Nishimura, Aya Kugimiya, Hideo Naoki, Nobuyuki Hamanaka

Sanyo Chemical Laboratory Co. Ltd, Tajii, Mihara-ku, Sakai, Osaka, Japan. nishimura@sanyokagaku.co.jp

Bioorganic & medicinal chemistry letters 2012 Apr 15

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Two pyrrolidine compounds (1 and 2) were isolated from photo-degradation of Bi-Sifrol tablets. Compound 1 was esterified to p-bromophenacyl ester as single-crystal, and then the structure was elucidated by single-crystal X-ray study. Compound 2 was determined by 2D NMR and mass spectra. Otherwise, we established that the photo-degradation of pramipexole was smoothly carried out in the methanol solution, and elucidate the degradation mechanism. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Eiji Nishimura, Aya Kugimiya, Hideo Naoki, Nobuyuki Hamanaka. Photo-degradation products of pramipexole. Bioorganic & medicinal chemistry letters. 2012 Apr 15;22(8):2951-3