Jean-Frédéric Sanchez, Brice Kauffmann, Axelle Grélard, Corinne Sanchez, Véronique Trézéguet, Ivan Huc, Guy J-M Lauquin
Université de Bordeaux, IBGC, UMR5095, Laboratoire de Physiologie Moléculaire et Cellulaire, Bordeaux, France.
Bioorganic & medicinal chemistry letters 2012 Apr 15Atractyloside (ATR) was characterized in 1868 and until now structural studies on diterpenic moiety had been done through the characterization of ATR derivatives; while the glycosidic moiety seemed to be a β-D-glucopyranose a recent crystal structure of the mitochondrial ATP/ADP carrier in complex with CATR showed an α-D-glucopyranose. We decided to re-examine the ATR and CATR structures by crystallographic study of ATR. Copyright © 2012 Elsevier Ltd. All rights reserved.
Jean-Frédéric Sanchez, Brice Kauffmann, Axelle Grélard, Corinne Sanchez, Véronique Trézéguet, Ivan Huc, Guy J-M Lauquin. Unambiguous structure of atractyloside and carboxyatractyloside. Bioorganic & medicinal chemistry letters. 2012 Apr 15;22(8):2973-5
PMID: 22425567
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