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Cyclooxygenase-2 and endothelial nitric oxide (NO) synthase enzymes may have a role in developing preclinical atherosclerosis. Designed groups were as follows: smoke exposed rats before and during pregnancy, only before pregnancy, and controls. Cross-sectional samples of abdominal aorta were examined immunohistochemically. Cyclooxygenase-2 and eNOS expression was evaluated semi-quantitatively through staining extent (focal, diffuse) and staining intensity. Diffuse COX-2 expression was detected in study groups. Endothelial NO synthase expression was diffuse in study groups. COX-2 and eNOS may contribute to the formation of preatherosclerotic lesions in offspring of rats exposed to cigarette smoke through inflammatory response.


Abdulbaki Karaoglu, Turan Tunc, Gokhan Aydemir, Onder Onguru, Bulent Uysal, Mustafa Kul, Secil Aydinoz, Emin Oztas, Umit Sarici. Role of cyclooxygenase 2 and endothelial nitric oxide synthetase in preclinical atherosclerosis. Fetal and pediatric pathology. 2012 Dec;31(6):432-8

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PMID: 22443285

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