Fragrance material review on 3-ethyl-2-hydroxy-2-cyclopenten-1-one.
J Scognamiglio, L Jones, C S Letizia, A M Api
Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. jscognamiglio@rifm.org
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 OctA toxicologic and dermatologic review of 3-ethyl-2-hydroxy-2-cyclopenten-1-one when used as a fragrance ingredient is presented. 3-Ethyl-2-hydroxy-2-cyclopenten-1-one is a member of the fragrance structural group ketones cyclopentanones and cyclopentenones. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 3-ethyl-2-hydroxy-2-cyclopenten-1-one were evaluated then summarized and includes physical properties, skin irritation, skin sensitization, and genotoxicity data. A safety assessment of the entire ketones cyclopentanones and cyclopentenones will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all ketones cyclopentanones and cyclopentenones in fragrances. Copyright © 2012 Elsevier Ltd. All rights reserved.
Citation
J Scognamiglio, L Jones, C S Letizia, A M Api. Fragrance material review on 3-ethyl-2-hydroxy-2-cyclopenten-1-one. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Oct;50 Suppl 3:S646-9
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PMID: 22445667
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