Metal ion-binding properties of DNA duplexes containing thiopyrimidine base pairs.

Itaru Okamoto, Takashi Ono, Rimi Sameshima, Akira Ono

Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan. i-okamoto@kanagawa-u.ac.jp

Chemical communications (Cambridge, England) 2012 May 7

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Thiopyrimidine pairs in DNA duplexes were unexpectedly largely stabilized by complexation with two equivalents of Ag(I) ions and their binding properties were evaluated. The metal ion-binding properties of the thiopyrimidine base pairs differed significantly from those of unpaired bases.

Citation

Itaru Okamoto, Takashi Ono, Rimi Sameshima, Akira Ono. Metal ion-binding properties of DNA duplexes containing thiopyrimidine base pairs. Chemical communications (Cambridge, England). 2012 May 7;48(36):4347-9