A study on the resolution of a terahertz spectrometer for the assessment of the porosity of pharmaceutical tablets.

Tuomas Ervasti, Pertti Silfsten, Jarkko Ketolainen, Kai-Erik Peiponen

School of Pharmacy, Promis Centre, University of Eastern Finland, P. O. Box 1627, FI-70211 Kuopio, Finland. tuomas.ervasti@uef.fi

Applied spectroscopy 2012 Mar

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In this study, the resolution of a time-domain terahertz spectrometer for tablet porosity measurements was estimated using two sets of pharmaceutical tablets. One set consisted of tablets with constant thickness and with porosity as a variable. The other set consisted of tablets with variable thickness and only a relatively small change in porosity. The set with constant thickness was used for the calibration of the terahertz (THz) spectrometer for the porosity measurements, and the resolution of the terahertz spectrometer was estimated using the set with different thicknesses and slightly different porosities. It was shown that a time-domain THz spectrometer is a sensitive device that allows monitoring of minute changes in the porosity of pharmaceutical tablets by detecting the time delay of the THz pulse, which is attributable to different refractive indices within the tablet. © 2012 Society for Applied Spectroscopy

Citation

Tuomas Ervasti, Pertti Silfsten, Jarkko Ketolainen, Kai-Erik Peiponen. A study on the resolution of a terahertz spectrometer for the assessment of the porosity of pharmaceutical tablets. Applied spectroscopy. 2012 Mar;66(3):319-23