Effects of long-term microgravitation exposure on cell respiration of the rat musculus soleus fibers.

O M Veselova, I V Ogneva, I M Larina

Institute of Biomedical Problems, the Russian Academy of Sciences, Moscow, Russia.

Bulletin of experimental biology and medicine 2011 Jul

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Cell respiration of the m. soleus fibers was studied in Wistar rats treated with succinic acid and exposed to microgravitation for 35 days. The results indicated that respiration rates during utilization of endogenous and exogenous substrates and the maximum respiration rate decreased in animals subjected to microgravitation without succinate treatment. The respiration rate during utilization of exogenous substrate did not increase in comparison with that on endogenous substrates. Succinic acid prevented the decrease in respiration rate on endogenous substrates and the maximum respiration rate. On the other hand, the respiration rate on exogenous substrates was reduced in vivarium control rats receiving succinate in comparison with intact control group. That could indicate changed efficiency of complex I of the respiratory chain due to reciprocal regulation of the tricarbonic acid cycle.

Citation

O M Veselova, I V Ogneva, I M Larina. Effects of long-term microgravitation exposure on cell respiration of the rat musculus soleus fibers. Bulletin of experimental biology and medicine. 2011 Jul;151(3):318-20