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In this case series, we describe four cases in which the use of gamma interferon release assays with purified protein derivative (PPD) as a stimulating antigen was able to demonstrate PPD-specific immune activation. This may help to improve the adequate diagnosis of (systemic) Mycobacterium bovis BCG infections after intravesical BCG instillations for bladder carcinoma.

Citation

Karen A Heemstra, Ailko W J Bossink, Roan Spermon, John J M Bouwman, Robert van der Kieft, Steven F T Thijsen. Added value of use of a purified protein derivative-based enzyme-linked immunosorbent spot assay for patients with Mycobacterium bovis BCG infection after intravesical BCG instillations. Clinical and vaccine immunology : CVI. 2012 Jun;19(6):974-7

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PMID: 22461529

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