Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Most advanced solid tumors remain incurable, with resistance to chemotherapeutics and targeted therapies a common cause of poor clinical outcome. Intratumor heterogeneity may contribute to this failure by initiating phenotypic diversity enabling drug resistance to emerge and by introducing tumor sampling bias. Envisaging tumor growth as a Darwinian tree with the trunk representing ubiquitous mutations and the branches representing heterogeneous mutations may help in drug discovery and the development of predictive biomarkers of drug response.

Citation

Timothy A Yap, Marco Gerlinger, P Andrew Futreal, Lajos Pusztai, Charles Swanton. Intratumor heterogeneity: seeing the wood for the trees. Science translational medicine. 2012 Mar 28;4(127):127ps10

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 22461637

View Full Text