Ti-catalyzed homolytic opening of ozonides: a sustainable C-C bond-forming reaction.

The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is reported. This novel reaction proceeds at room temperature under neutral, mild conditions compatible with many functional groups and provides carbon radicals suitable to form C-C bonds via both homocoupling and cross-coupling processes. The procedure has been advantageously exploited for the straightforward synthesis of the natural product brittonin A. © 2012 American Chemical Society

Citation

Antonio Rosales, Juan Muñoz-Bascón, Cristóbal López-Sánchez, Míriam Álvarez-Corral, Manuel Muñoz-Dorado, Ignacio Rodríguez-García, J Enrique Oltra. Ti-catalyzed homolytic opening of ozonides: a sustainable C-C bond-forming reaction. The Journal of organic chemistry. 2012 Apr 20;77(8):4171-6

PMID: 22463489

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