Does complement play a role in bone development and regeneration?

Philipp Schoengraf, John D Lambris, Stefan Recknagel, Ludwika Kreja, Astrid Liedert, Rolf E Brenner, Markus Huber-Lang, Anita Ignatius

Institute of Orthopaedic Research and Biomechanics, Centre of Muskuloskelettal Research, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany.

Immunobiology 2013 Jan

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The skeletal and the immune system are not two independent systems, rather, there are multifaceted and complex interactions between the different cell types of both systems and there are several shared cytokines. As a part of the innate immunity, the complement system was found to be an important link between bone and immunity. Complement proteins appear to be involved in bone development and homeostasis, and specifically influence osteoblast and osteoclast activity. This review describes the complex mutual regulation of the two systems, and indicates some of the negative side effects as a result of inappropriate or excessive complement activation. Copyright © 2012 Elsevier GmbH. All rights reserved.

Citation

Philipp Schoengraf, John D Lambris, Stefan Recknagel, Ludwika Kreja, Astrid Liedert, Rolf E Brenner, Markus Huber-Lang, Anita Ignatius. Does complement play a role in bone development and regeneration? Immunobiology. 2013 Jan;218(1):1-9