Predicting the absorption of chemical vapours.

Matias Rauma, Anders Boman, Gunnar Johanson

Unit of Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Sweden. matias.rauma@ki.se

Advanced drug delivery reviews 2013 Feb

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The focus of this review is on the systemic absorption of vapours via skin, including experimental data as well as regression and pharmacokinetic models. Dermal contribution ratios (DCR), i.e. amount absorbed through skin relative to total intake (skin and inhalation) at specified conditions, could be identified or calculated from published data for 33 chemical vapours. The ratios vary from ~0.0002 (vinyl chloride) to ~0.8 (2-butoxyethanol), with hydrophilic chemicals having a higher ratio than lipophilic ones. Multiple regression analysis of these data suggests that the DCR is largely explained by the octanol:water partition coefficient, vapour pressure and molecular weight (R(2)=0.69). Several physiologically-based pharmacokinetic models were identified; however, all describe the absorption of single substances. Regarding predictive models, only two models were found. In conclusion, dermal uptake of chemical vapours needs more attention, as such exposures are common, data are scarce and few predictive models exist. Copyright © 2012 Elsevier B.V. All rights reserved.